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Visum Therapeutics
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Spatial Transcriptomics Inc
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Image Search Results
Journal: Advanced Science
Article Title: Identification of a Novel ECM Remodeling Macrophage Subset in AKI to CKD Transition by Integrative Spatial and Single‐Cell Analysis
doi: 10.1002/advs.202309752
Figure Lengend Snippet: Spatiotemporal dynamics of main cell types after UIR. a) H&E staining of Visium Spatial Gene Expression samples. b) Representative Masson images at each timepoint. c,d) UMAP of spatial transcriptomics spots based on cell‐type compositions and the injury score in spatial transcriptomics. e)Injury scores in each time points. The arrows point to the areas with the highest injury score. f,g,h) The proportions of macrophages, neutrophils and multiple cells were deconvoluted from the scRNA‐seq data using the cell2location algorithm. Max, maximum; min, minimum. i) The proportion of macrophages and neutrophils infiltrated into each area according to the time‐point after UIR. j) Median relevance of cell‐type abundance in predicting other cell‐type abundances within a location.
Article Snippet: The
Techniques: Staining, Gene Expression
Journal: Advanced Science
Article Title: Identification of a Novel ECM Remodeling Macrophage Subset in AKI to CKD Transition by Integrative Spatial and Single‐Cell Analysis
doi: 10.1002/advs.202309752
Figure Lengend Snippet: Characteristics of ECM remodeling macrophages. a) Expression of representative ECM‐related genes in EAMs after UIR. b) Gene expression of Tgfbi and Mmp9 in spatial transcriptomics dataset. c) Expression of representative lipid metabolism‐related genes. d) Gene expression of Fabp5 and Pla2g7 in spatial transcriptomics dataset. e) Gene Ontology terms enriched from the differentially expressed genes of EAMs compared to all other Mac clusters in each time points. f) Inflammation, fibrosis and ECM scores of EAMs in each time points. g) Gene expression of Igf1 and Mmp12 in spatial transcriptomics dataset.
Article Snippet: The
Techniques: Expressing, Gene Expression